Figure 4.
Searching for synergy in CTCL cell lines. (A-D) Four CTCL cell lines were tested for synergy between venetoclax and vorinostat, and between venetoclax and romidepsin. Cell lines were first incubated with incremental increase of each of the 3 drugs individually to calculate IC50 values. Next, cell lines were incubated with combinations of each drug in an approximate 1:1 ratio of the calculated IC50 values. Synergy was noted between venetoclax and vorinostat in the MyLa cell line and between venetoclax and with high doses of romidepsin in the HH cell line.
