Changes in genetic expression of BCL2 family members following incubation with vorinostat or romidepsin. (A) Significant changes include the increased expression of BCL2L11, BMF, and MCL1. Notable is the 2.7-fold increase in BCL2 expression in the MyLa cell line with vorinostat. (B) The amount of calculated synergy, represented by the CI at 0.9 fraction affected (10% viability), was correlated to change in expression of venetoclax after 24 hours of incubation with 5 µM vorinostat, a strong correlation was noted, but only limited conclusions can be drawn, due to the small sample size.