Figure 1.
Figure 1. Procoagulant attributes and causative mechanisms of candidate procoagulant platelets. Platelet phenotypes by their published names or by their unique features as follows: (1) BP/ballooned non-spread platelets (BNS)8,10,17; (2) SCIP17; (3) BAPS platelets,8,18 high-density bubble-shaped (HDBS) platelets also show similar features19; (4) FIB-CAP,20,21 characterized by PS exposure, the lack of active integrin αIIbβ3, and the retention of fibrinogen and thrombospondin as a single patch or cap on the procoagulant platelets; (5) 4-[N-(S-glutathionylacetyl) amino] phenylarsonic acid (GSAO) binding procoagulant platelets22,23; (6) procoagulant platelets dependent on the formation/opening of MPTP24-28; and (7) collagen and thrombin-activated (COATED) platelets.11,26-30 BP, SCIP, BAPS, and FIB-CAP platelets are broadly referred to as ballooning/BPs, whereas GSAO, MPTP, and COATED platelets are broadly classified as MPTP phenotype. The procoagulant attributes are qualitative features of procoagulant platelets, which we scored 100 for “Yes,” 0 for “No,” and 50 for transient features or “Yes/No.” Features based on the “causative mechanisms” are quantitative; for this we assigned values based on published fractional responses or the reported percentage procoagulant platelets formed. We then present these data as a color map where the upper, middle, and lower end of a 0 to 100 scale is represented by red, yellow, and blue, respectively. To determine the characteristic features of the procoagulant platelet based on pooled data, we used the mean value for each feature across candidates of the procoagulant platelet (BP, BNS, HDBS, FIB-CAP, SCIP, BAPS, GSAO, COATED, and MPTP), as shown in the corresponding row of the “PROCOAG ID” column. The color map was generated using Prism 7 (GraphPad software). White spaces within the map represent unknown parameters, whereas the black column demarcates the individual scores from the mean score in the “PROCOAG ID” column. vWF, Von Willebrand factor.

Procoagulant attributes and causative mechanisms of candidate procoagulant platelets. Platelet phenotypes by their published names or by their unique features as follows: (1) BP/ballooned non-spread platelets (BNS)8,10,17 ; (2) SCIP17 ; (3) BAPS platelets,8,18  high-density bubble-shaped (HDBS) platelets also show similar features19 ; (4) FIB-CAP,20,21  characterized by PS exposure, the lack of active integrin αIIbβ3, and the retention of fibrinogen and thrombospondin as a single patch or cap on the procoagulant platelets; (5) 4-[N-(S-glutathionylacetyl) amino] phenylarsonic acid (GSAO) binding procoagulant platelets22,23 ; (6) procoagulant platelets dependent on the formation/opening of MPTP24-28 ; and (7) collagen and thrombin-activated (COATED) platelets.11,26-30  BP, SCIP, BAPS, and FIB-CAP platelets are broadly referred to as ballooning/BPs, whereas GSAO, MPTP, and COATED platelets are broadly classified as MPTP phenotype. The procoagulant attributes are qualitative features of procoagulant platelets, which we scored 100 for “Yes,” 0 for “No,” and 50 for transient features or “Yes/No.” Features based on the “causative mechanisms” are quantitative; for this we assigned values based on published fractional responses or the reported percentage procoagulant platelets formed. We then present these data as a color map where the upper, middle, and lower end of a 0 to 100 scale is represented by red, yellow, and blue, respectively. To determine the characteristic features of the procoagulant platelet based on pooled data, we used the mean value for each feature across candidates of the procoagulant platelet (BP, BNS, HDBS, FIB-CAP, SCIP, BAPS, GSAO, COATED, and MPTP), as shown in the corresponding row of the “PROCOAG ID” column. The color map was generated using Prism 7 (GraphPad software). White spaces within the map represent unknown parameters, whereas the black column demarcates the individual scores from the mean score in the “PROCOAG ID” column. vWF, Von Willebrand factor.

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