Subphenotypes of SCD, measurable markers, and clinical complications. ASAT, aspartate aminotransferase; Hb, hemoglobin; LDH, lactate dehydrogenase; NT-proBNP, N-terminal prohormone of brain natriuretic peptide; TRV, tricuspid regurgitant jet velocity. Adapted from Figure 2 in Kato et al.⁷