KIT D816V EAB changes on midostaurin. (A) Mean percent change (±SE) of the KIT D816V EAB in PB from baseline in 28 advSM patients treated with midostaurin. (B) Waterfall plot of the best percentage change of KIT D816V EAB in individual patients at any time. EAB changes over time in individual patients with ≥25% (C) or <25% (D) reduction of KIT D816V EAB at month 6. SE, standard error.