Chronic elevation of circulating sP-selectin does not promote inflammation and coagulation. (A-B) Number of rolling cells and arrested cells in trauma-stimulated venules of WT or Tg-sP-selectin mice in the presence or absence of blocking anti-P-selectin mAb or anti-β2 integrin mAb. (C) Plasma-clotting times of WT or Tg-sP-selectin mice without challenge or 4 hours after intraperitoneal injection of lipopolysaccharide (LPS). (D-F) Frequency of thrombus, thrombus length, and thrombus weight in WT or Tg-sP-selectin mice 48 hours after ligation of inferior vena cava. The data in panels A and B represent the mean ± SEM from 11 to 15 venules from 5 to 6 mice in each group. The data in panels D-F represent the mean ± SEM from 15 experiments in each group. *P < .05.