New WHO classification of lymphoma. Regardless of morphology, if myc and bcl-2 rearrangements are present, they are now categorized as high-grade B-cell lymphoma with myc and bcl-2 and/or bcl-6 rearrangements. HGBL, high-grade B-cell lymphoma; NOS, not otherwise specified. Adapted from Swerdlow et al.²¹