Incidence of bleeding during EXTEND (WHO bleeding scale) up to week 117. Bleeding assessments were performed weekly and then monthly or every 2 months for patients with a stable dose of eltrombopag. WHO grade 1, petechiae; grade 2, mild blood loss; grade 3, gross blood loss; grade 4, debilitating blood loss. One patient had WHO grade 4 bleeding, which occurred at week 24. Another patient had grade 4 bleeding during follow-up.