Figure 5.
c-MPL signaling in tumor-targeted TCR-transgenic T cells is immune stimulatory. (A) Heat map of median normalized differential gene expression clustered by overall expression behavior. (B) Control signal mean normalized expression behavior of highlighted clusters from heat map. (C) Gene set enrichment analysis output for reactome interferon α β signaling gene set showing correlation between control and EP treatment, and control and TPO treatment. (D) Heat map of enriched genes in interferon α β signaling genes. (E) Genes in the overlap of the control vs EP and control vs TPO differential genes.