Clinical course of patients 1 and 2. (A-B) Medications administered during cycles of treatment are shown at the top of each panel. Dexamethasone (DX) was continued for 3 days after each episode of thrombocytopenia in patient 1 (horizontal arrows). Platelet and red blood cell (RBC) transfusions and intravenous immunoglobulin (IVIg) infusions are indicated by vertical arrows. Days (x-axis) are numbered from the first cycle of chemotherapy that was followed by an episode of thrombocytopenia. IR, irinotecan; LE, leucovorin; OX, oxaliplatin.