Figure 3.
Figure 3. LE2E9- and mAb 2A9-mediated inhibition of the functional activity of hC1pfVIII variants in coagulation assays. The inhibition of the functional activity of hC1pfVIII and its variants E2066D and F2068H by LE2E9 (A) and mAb 2A9 (B) was measured in a 1-stage clotting assay (for experimental details, see “Methods”). LE2E9 and mAb 2A9 concentrations before mixing with hC1pfVIII variants are indicated.

LE2E9- and mAb 2A9-mediated inhibition of the functional activity of hC1pfVIII variants in coagulation assays. The inhibition of the functional activity of hC1pfVIII and its variants E2066D and F2068H by LE2E9 (A) and mAb 2A9 (B) was measured in a 1-stage clotting assay (for experimental details, see “Methods”). LE2E9 and mAb 2A9 concentrations before mixing with hC1pfVIII variants are indicated.

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