Morphological changes and knobs formation in late maturation stages induced by Syk inhibitors. Representative pictures of parasites at 48 hours postinfection in control and in R406-treated cultures selected (A) from Diff-Quik fix stained thin blood films and (B) representative picture of asexual late trophozoite (i) untreated or treated with R406 (ii) 2.5 μΜ and (iii) 5 μΜ obtained by SEM.