Different patterns of chronic IL-18 in MAS-prone patients. Time course of cytokine and disease activity measurements in a patient with (A) NLRC4-associated MAS, (B) idiopathic MAS, and (C) adult-onset Still disease presenting with MAS. Dashed lines crossing the y-axes indicate upper limits of normal . In panel A, influenza vaccination is indicated by asterisks along the x-axis. CRP in milligram/liter, ferritin in nanogram/milliliter, all others in picogram/milliliter.