Figure 4.
Figure 4. Mice bearing Nlrc4T337S mutation have chronic, inflammasome-dependent IL-18 elevation. (A) Serum IL-18 from age- and sex-matched NLRC4T337S/T337S, NLRC4T337S/WT, and WT mice. (B) NLRC4T337S/WT mice or littermate controls were assessed for serum IL-18 upon weaning at 21 days of age. (C) Serum was obtained from NLRC4T337S/T337S and WT mice housed separately until 7 weeks of age, then cohoused for 4 weeks, and then cohoused and administered broad-spectrum antibiotics for an additional 4 weeks. (D) Serum IL-18 was assessed in mice of the indicated genotypes. Each graph is representative of at least 2 separate experiments. ***P < .001, ***P < .0001, 1-way analysis of variance (ANOVA) with Tukey posttest.

Mice bearing Nlrc4T337Smutation have chronic, inflammasome-dependent IL-18 elevation. (A) Serum IL-18 from age- and sex-matched NLRC4T337S/T337S, NLRC4T337S/WT, and WT mice. (B) NLRC4T337S/WT mice or littermate controls were assessed for serum IL-18 upon weaning at 21 days of age. (C) Serum was obtained from NLRC4T337S/T337S and WT mice housed separately until 7 weeks of age, then cohoused for 4 weeks, and then cohoused and administered broad-spectrum antibiotics for an additional 4 weeks. (D) Serum IL-18 was assessed in mice of the indicated genotypes. Each graph is representative of at least 2 separate experiments. ***P < .001, ***P < .0001, 1-way analysis of variance (ANOVA) with Tukey posttest.

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