Survival analysis using Cox proportional hazard model. Baseline was defined as subjects who were neither WGS-outliers nor carriers of a mosaic somatic CD mutation. Plots show HRs with 95% confidence intervals. (A) HRs for all-cause mortality adjusted for age at blood draw, year of birth, sex, previous diagnoses of cancer, and smoking. (B) HRs for subsequent hematological malignancy adjusted for age at blood draw and year of birth. Details of the subjects who developed hematological malignancies are shown in supplemental Table 6.