Prevalence and distribution of somatic mutations in aging hematopoiesis. (A) Age distribution of the 2530 women of the cohort. (B) Prevalence of somatic mutation in the 347 mutated individuals of the cohort; the pale blue shade represents 95% confidence interval. (C) Distribution of the types of single-nucleotide substitutions observed in somatic variants of the cohort. (D) Allelic fraction distribution of the 402 somatic mutations observed. (E) Contribution of individual genes to the total number of observed somatic mutations. VAF, variant allele fraction.