Schematic diagram of DNMT3A and TET2 mutations. (A) Distribution of the 230 somatic mutations observed in DNMT3A. (B) Distribution of the 134 somatic mutations observed in TET2. Blue dots, missense mutations; red dots, truncating mutations (frame shift, nonsense and splice site); gray dots, in-frame deletions or insertions; purple, residues that are affected by different mutation types at the same proportion. The height of the line is proportional to the number of observations (from 1 to 21).