Preferential recovery of aggregation of ERp72-, PDI-, and ERp57-null platelets by the specific PDI that is deleted. (A) ERp72-null platelets were incubated with 150 nM PDI or ERp57 (as in Figure 3D). (B) PDI-null platelets were incubated with 100 nM ERp57, ERp72, or PDI. (C) ERp57-null platelets were incubated with 100 nM ERp57, ERp72, or PDI. (A-C) Platelet aggregation was stimulated using thrombin (0.015 U/mL) (right); cumulative data, mean ± SEM, n = 3, *P < .05, **P < .01, ***P < .001, analysis of variance. ERp72^fl/fl, PDI^fl/fl, and ERp57^fl/fl represent the Cre-negative littermate controls. NS, not significant.