SOX11/FAK axis promotes proliferation of MCL in contact with marrow stromal cells. (A) Z138CT, Z138KD, JVM2CT, and JVM2SOX11⁺ MCL cell lines untreated (Ø) or pretreated with PF were cocultured with BM stromal SNKT-GFP⁺ cells. The number of MCL cells was counted by FC after 3 days of coculture. (B) Z138CT and Z138KD MCL cells (solid circle) were seeded in a 5:1 ratio: (1) with SNKT-GFP⁺ cells (shown in green) on a transwell insert, (2) with a coculture of SNKT-GFP⁺ and MCL cells on the transwell insert, and (3) in direct coculture with SNKT-GFP⁺ cells. The number of MCL cells was counted by FC after 48 hours of coculture. Values are represented as percentage of increment in the number of MCL cells relative to the number of cells at day 0. Bar plot represents the mean percentage ± standard deviation of 3 independent experiments. The significance of difference was determined by independent samples Student t test: *P < .05, ***P < .001.