Incidence of grade II to IV aGVHD, grade III to IV aGVHD, and TRM by matching at HLA-DPB1 locus. Nonpermissive GVH HLA-DPB1 mismatches increased the risks for grade II to IV aGVHD (A), grade III to IV aGVHD (B), and 1-year TRM (C). The highest risk for grade II to IV aGVHD was observed in HLA-DPB1–mismatched nonpermissive GVH pairs with an incidence of 44% followed by pairs mismatched nonpermissive HVG and permissive HVG, with incidences of 37% and 35%, respectively. The incidence of grade III to IV aGVHD was also the highest in the nonpermissive GVH HLA-DPB1–mismatched pairs with an incidence of 12%. Pairs that are matched, mismatched permissive and mismatched nonpermissive HVG had similar incidences of grade III-IV aGVHD with 5%, 5%, and 9%, respectively. TRM at 1 year was 25% in nonpermissive GVH HLA-DPB1–mismatched pairs. Mismatched pairs that are nonpermissive HVG and permissive had similar cumulative incidences of 1 year TRM with 21% and 20%, whereas matched pairs had 14% at 1 year.