The inhibition efficacy of HP6H8 against P falciparum. (A) In vitro invasion assay of HP6H8 against P falciparum strains (Dd2, 3D7, FCC1, and Nf54) and parasites isolated from the field (n = 3). (B) Parasitemia after administration of HP6H8 in huRBC-engrafted NOG mice. Lines show doses of HP6H8 at 0.016, 0.08, 0.4, 2, and 10 mg/kg, placebo group, and IgG 10 mg/kg group (n = 5, 3, 6, 6, 5, 4, and 4, respectively). Data shown are mean ± SD. (C) Inhibition efficacy of HP6H8 in humanized mice. Red line represents the best fitting curve.