Mean plasminogen activity levels after the first and week 12 doses of plasminogen (human). (A) Mean plasminogen activity levels after the first dose of plasminogen (human) in 14 patients with hypoplasminogenemia; this includes 6 patients (1 child and 5 adults) who received a single 6-mg/kg dose in the phase 1 study (2002C005G) and 8 patients (4 children and 4 adults) who received a single 6.6-mg/kg dose in the phase 2/3 study. (B) Mean plasminogen activity levels after the week 12 dose of 6.6 mg/kg plasminogen (human) in the same 14 patients.