In the spleen, B cells consume most of the BAFF secreted by neutrophils. The antibody-secreted cell population is dominated by short-lived plasma cells (SLPCs). After depletion of B cells by an anti-CD20 antibody, the availability of BAFF increases, sustaining the emergence of LLPCs. The combination of the anti-CD20 antibody with an anti-BAFF antibody results in amplified B-cell apoptosis and exhaustion of the LLPC niche.