Representative findings in 2 patients with IFI. Patient 1 had been receiving ibrutinib 420 mg/d for 4 months for CLL associated with grade 3 autoimmune neutropenia when she complained of gait disorder. Computed tomography scan (A) and T1-weighted magnetic resonance imaging with gadolinium injection (B) revealed a solitary abscess of the vermis. Neurosurgical drainage disclosed Aspergillus fumigatus. Patient 2 was hospitalized after a third cycle of bendamustine, rituximab, ibrutinib for fever, cough, and confusion. Chest computed tomography scan revealed multiple pulmonary nodules (C-D) and T2-weighted fluid attenuation inversion recovery (FLAIR) magnetic resonance imaging multiple cerebral abscesses (E-F). Aspergillus antigenemia was strongly positive, and Aspergillus fumigatus was isolated in the bronchoalveolar lavage.