Aberrations in the JAK-STAT pathway in PMBCL. The frequency and presence of aberrations affecting 5 genes (SOCS1, STAT6, JAK2, PTPN1, IL4R) are displayed in the first 5 rows for 30 PMBCL patients. Each column represents a patient, and rows are ordered by the presence of mutations from the most to the least frequently mutated gene. For each patient, IHC analysis of CD23, CCL17, and pSTAT6 are displayed (staining is considered positive when the percentage of positive cells is ≥10%); significant correlation was evaluated using 2-sided Fisher exact test. **P < .01; ***P < .001. Gray, data not evaluable. (B) Representative IHC sections stained with H&E, CD23, pSTAT6, and CCL17. Images were acquired using an Eclipse E600 microscope, DS-F1 camera, and DS-L2 acquisition software (Nikon); original magnification ×40; numerical aperture of objective lenses, 0.75.