Figure 2.
Figure 2. Myo1f-deficient neutrophils failed to extravasate in an acute lung injury model and during acute peritonitis. (A) Ratios of Myo1f+/+ and Myo1f−/− neutrophils extravasated into the interstitium (i) or the bronchoalveolar space (ii) to neutrophils remaining in the lung vasculature, 4 hours upon exposure to aerosolized NaCl or LPS for 30 minutes. n = 4; mean ± SEM; **P < .01 (2-way ANOVA, Tukey multiple comparison test). (B) Lung damage was assessed by quantification of tetramethylrhodamine isothiocyanate (TRITC)-Dextran clearance. n = 4; mean ± SEM; **P < .01 (unpaired Student t test). (C) Total number of extravasated neutrophils in the peritoneal lavage 4 hours after intraperitoneal injection of CXCL1 (300 ng per animal). n = 6; mean ± SEM; ***P < .001 (unpaired Student t test).

Myo1f-deficient neutrophils failed to extravasate in an acute lung injury model and during acute peritonitis. (A) Ratios of Myo1f+/+ and Myo1f−/− neutrophils extravasated into the interstitium (i) or the bronchoalveolar space (ii) to neutrophils remaining in the lung vasculature, 4 hours upon exposure to aerosolized NaCl or LPS for 30 minutes. n = 4; mean ± SEM; **P < .01 (2-way ANOVA, Tukey multiple comparison test). (B) Lung damage was assessed by quantification of tetramethylrhodamine isothiocyanate (TRITC)-Dextran clearance. n = 4; mean ± SEM; **P < .01 (unpaired Student t test). (C) Total number of extravasated neutrophils in the peritoneal lavage 4 hours after intraperitoneal injection of CXCL1 (300 ng per animal). n = 6; mean ± SEM; ***P < .001 (unpaired Student t test).

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal