Figure 1.
Figure 1. Epigenetic regulation of miR-125b expression in B lymphocytes. (A) Relative miR-125b expression in the bone marrow, spleen, and various immune cells. The expression of miR-125b-5p and miR-125b-1-3p was measured using TaqMan reverse transcription qPCR (n = 3). (B) Relative miR-125b expression in HSPCs (L−S+K+) and various B-lymphocyte subsets. (C) Modification patterns of H3K14Ac, H3K36Ac, H3K4me3, H3K79me2, H4K91ac, and H3K27me3, as well as PolII and p300 recruitment in the loci encoding miR-125b and miR-15a/16-1 in resting mature B cells. IL, interleukin; LPS, lipopolysaccharide.

Epigenetic regulation of miR-125b expression in B lymphocytes. (A) Relative miR-125b expression in the bone marrow, spleen, and various immune cells. The expression of miR-125b-5p and miR-125b-1-3p was measured using TaqMan reverse transcription qPCR (n = 3). (B) Relative miR-125b expression in HSPCs (L−S+K+) and various B-lymphocyte subsets. (C) Modification patterns of H3K14Ac, H3K36Ac, H3K4me3, H3K79me2, H4K91ac, and H3K27me3, as well as PolII and p300 recruitment in the loci encoding miR-125b and miR-15a/16-1 in resting mature B cells. IL, interleukin; LPS, lipopolysaccharide.

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