Figure 1.
The differential response of primed vs unprimed mitochondria to a BCL-2 selective BH3 mimetic. In the case of a primed cell (top), BCL-2-bound-BIM (or activated BAX) can be displaced by the BCL-2 antagonist to induce BAX or BAK dependent MOMP, irreversibly committing the AML cell to death. In the case of an unprimed cell (bottom), treatment with the BCL-2 antagonist does not induce MOMP due to the lack of proapoptotic proteins prebound to the BCL-2. Reprinted from Potter and Letai24 with permission.
