Effect of patient subgroup on PFS. *Number of events per number of patients. †Complete cytogenetics profile for 501 patients (248 in Rd continuous and 253 in MPT); high-risk cytogenetics included t(4;14), t(14;16), and del(17p). cont, continuous; CrCl, creatinine clearance; ECOG PS, Eastern Cooperative Oncology Group performance status; ISS, International Staging System.