My approach to allo-SCT in CLL. Treatment algorithm for CLL patients who might be considered candidates for allo-SCT. Patients who require treatment who have no TP53 abnormality are candidates for chemoimmunotherapy (CIT) or a clinical trial, and those with TP53 abnormalities are candidates for ibrutinib front line. Patients who are relapsed or refractory (R/R) can be treated with ibrutinib or another BTKi or venetoclax plus rituximab. Patients who have relapsed after or are intolerant to ibrutinib are candidates for venetoclax, and those who have failed venetoclax plus rituximab are candidates for ibrutinib. Patients responding to second novel agent can either proceed to allo-SCT or continue the novel agent.