Meta-regression based on combined CLL8, CLL10, and CLL11 patient populations (MRD-evaluable populations). Orange circles, CLL8; blue circles, CLL10; red circles, CLL11. Circle size in the figure reflects weighting of each subgroup to the overall model; those with least variability in PFS HR have the largest circle. Clustering of circles by trial reflects overall treatment effect for MRD and PFS in the trials.