SCD patients exhibit higher susceptibility and R2* in multiple subcortical nuclei, compared with age-matched controls. (A) Average susceptibility (ppb) and R2* (per second) of deep gray matter ROIs in SCD patients and healthy controls. Values are reported as mean (standard deviation). All values were corrected for age and sex; d is Cohen’s effect size, which is defined as the difference between group means divided by the pooled standard deviation. **P < .01; *P < .05. (B) Examples of susceptibility and R2* maps in the regions of substantia nigra and red nucleus. Susceptibility maps (top), R2* maps (middle), and T2*-weighted images at an echo time of 20 ms (bottom) are shown. Blue and pink dashed boxes highlight the regions of substantia nigra and red nucleus, respectively. The left 2 columns compare an SCD patient with a control, both of whom are 29 years old, and the right 2 columns compare 2 subjects who are both 25 years old.