Susceptibility values of multiple subcortical nuclei correlate with hemoglobin and white matter damage. (A) Age corrected susceptibility measurements present significant negative correlation with hemoglobin in substantia nigra (P = .008, r2 = 0.14), red nucleus (P = .028, r2 = 0.10), and dentate nucleus (P = .023, r2 = 0.13). Dotted lines show the linear regression of the data, and shaded areas delimit the 95% confidence interval. (B) Susceptibility of the globus pallidus and substantia nigra (after correction for age and sex) is higher in SCD patients with silent infarcts (SCI+), compared with patients with normal appearing white matter (SCI−). Mean and standard deviation of globus pallidus susceptibility are 180.5 ± 29.8 ppb in the SCI+ group and 149.3 ± 23.7 ppb in the SCI− group. **P = .007. Mean and standard deviation of substantia nigra susceptibility are 151.7 ± 35.5 ppb in the SCI+ group and 115.3 ± 29.1 ppb in the SCI− group. **P = .010