Figure 4.
Figure 4. Effect of FPI on ADAMTS-13−/− mice. VWF:CB (A) and VWF:Ag (B) of ADAMTS-13−/−-CASA mice preconditioned with rADAMTS-13 or PBS before being subjected to FPI. Control mice underwent sham surgery (n = 27; 1-way repeated measures ANOVA, *P < .01, **P < .001). (C) The effect of rADAMTS-13 preconditioning on dynamic changes in VWF:CB of ADAMTS-13−/− and C57 BL/6J mice during the first 24 hours after FPI (n = 18; 1-way ANOVA, *P < .01 vs sham). (D) Evans blue dye extravasation of brain tissues from ADAMTS-13−/− mice preconditioned with either rADAMTS-13 or PBS before FPI (n = 27; 1-way ANOVA, *P < .01). Plasma levels of D-dimer (E) and fibrinogen (F) of ADAMTS-13−/− mice from the above groups (n = 27; 1-way ANOVA, *P < .01). (G) Modified Neurological Severity Scores (mNSS; n = 27; 1-way-repeated measures ANOVA, *P < .001, **P < .01, ***P < .05) and (H) Kaplan-Meier survival plot (n = 76) of ADAMTS-13−/−-CASA mice in the above treatment groups.

Effect of FPI on ADAMTS-13−/−mice. VWF:CB (A) and VWF:Ag (B) of ADAMTS-13−/−-CASA mice preconditioned with rADAMTS-13 or PBS before being subjected to FPI. Control mice underwent sham surgery (n = 27; 1-way repeated measures ANOVA, *P < .01, **P < .001). (C) The effect of rADAMTS-13 preconditioning on dynamic changes in VWF:CB of ADAMTS-13−/− and C57 BL/6J mice during the first 24 hours after FPI (n = 18; 1-way ANOVA, *P < .01 vs sham). (D) Evans blue dye extravasation of brain tissues from ADAMTS-13−/− mice preconditioned with either rADAMTS-13 or PBS before FPI (n = 27; 1-way ANOVA, *P < .01). Plasma levels of D-dimer (E) and fibrinogen (F) of ADAMTS-13−/− mice from the above groups (n = 27; 1-way ANOVA, *P < .01). (G) Modified Neurological Severity Scores (mNSS; n = 27; 1-way-repeated measures ANOVA, *P < .001, **P < .01, ***P < .05) and (H) Kaplan-Meier survival plot (n = 76) of ADAMTS-13−/−-CASA mice in the above treatment groups.

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