BM histomorphologic changes at 24 and 48 months. A bar graph showing the percentage of evaluable patients who had improvement, stabilization, or progression in BM reticulin fibrosis, collagen, and osteosclerosis at 24 and 48 months compared with pretherapy. Changes in BM histomorphology (upper panel) at 24 months and (lower panel) at 48 months. BM response was classified as improvement, stabilization, or worsening. Patients with baseline BM fibrosis grade 3 were excluded from this analysis because progression and stabilization were not defined. Numerator identifies patients with a grade different than that at pretherapy. The denominator identifies eligible patients included in the analysis (eg, excludes patients with BM fibrosis grade 3 for worsening).