Infarct density map from 286 children with SCA and SCIs in the SIT Trial. Infarct density was calculated for each voxel as the sum of participants with a lesion in that voxel divided by the total number of participants evaluated in the cohort. (A) Infarct densities range from 1% to 18%, with greatest densities falling in the deep white matter of the frontal and parietal lobes. (B) The infarct density map was thresholded to determine the region which encompassed SCIs from 90% of the cohort. The volume of this region was 5.6% of total intracranial volume. *SCIs for 90% of children are located within a confined region (5.6% of total brain volume).