Hypothetical scheme of the migratory pathways of cells with Ig/c-myc recombinations in BALB/cAn mice. In untreated mice, cells carrying these recombinations are mainly found in the GALT and migrate between PPs and into the intestine where differentiation into plasma cells occurs. Following treatment with pristane, cells traffic between PPs, mesenteric lymph node, spleen, and into the developing OG. The environment of the granuloma causes an expansion of cells with Ig/c-myc recombinations and differentiation into plasma cells leading to the development of plasmacytic foci.1 This pristane-induced migration was mainly observed in BALB/cAn, whereas C57BL/6 and C3H/HeJ mice showed migration only within the GALT. The trafficking scheme is based on the detection of clonotypic c-myc recombination sequences in different organs.