Gene-expression–based L-MCL16 scores in the validation cohort. L-MCL16 score for each validation sample in ascending order (top panel) and associated probability of membership in the nnMCL subgroup (middle panel). L-MCL16 signature heat map (13 upregulated genes in cMCL and 3 upregulated genes in nnMCL) (bottom panel); genes are shown in rows, and cases are shown in columns (red indicates high expression). Two clear gene expression patterns can be observed, with high scores corresponding to cMCL samples (blue) and low scores corresponding to nnMCL samples (red). Only 5 samples have an intermediate gene-expression pattern and are considered Undetermined (gray).