Effect of soluble fibrinogen on PMN adhesion to fibrin with or without platelets. Neutrophils were perfused over Fb-flow (○) and Fb + platelets (□) at a shear stress of 80 mPa in the presence of different concentrations of soluble fibrinogen. Neutrophils were also suspended in anticoagulated autologous plasma (PL) or a human albumin solution (AL, 5 g/L) and perfused over Fb-flow. Data represent the total number of adhering neutrophils per mm2 as a percentage of the control perfusion with no fibrinogen added. Absolute control values are 1,005 ± 75 cells/mm2 for Fb-flow and 1,209 ± 173 for Fb + platelets. The mean ± SE of four to six experiments is shown. A significant effect of soluble fibrinogen on PMN adhesion to Fb-flow was determined by repeated-measures ANOVA (P < .01).