Fig. 6.
Fig. 6. Morphological characteristics of HL60 cells treated with c-fes ODN before and after induction to macrophage differentiation by 48 hours of PMA treatment. (A) ODN untreated HL60 cells; (B) ODN untreated HL60 cells induced to macrophage differentiation with PMA; (C) HL60 cells after 5 days of treatment with hFES-AS-sj1 and 2 ODN; (D) macrophage morphology observed when HL60 cells, pretreated for 5 days with hFES-S-sj1 and 2 ODN, are induced to differentiate with PMA; (E) macrophage morphology observed when HL60 cells, pretreated for 5 days with hFES-IP-sj1 and 2 ODN, are induced to differentiate with PMA; (F ) morphology of HL60 cells pretreated with hFES-AS-sj1 and 2 ODN and PMA induced. This panel is representative of the results obtained by several different experiments. Superimposable results are obtained with both the antisense strategies. Original magnification ×1,000.

Morphological characteristics of HL60 cells treated with c-fes ODN before and after induction to macrophage differentiation by 48 hours of PMA treatment. (A) ODN untreated HL60 cells; (B) ODN untreated HL60 cells induced to macrophage differentiation with PMA; (C) HL60 cells after 5 days of treatment with hFES-AS-sj1 and 2 ODN; (D) macrophage morphology observed when HL60 cells, pretreated for 5 days with hFES-S-sj1 and 2 ODN, are induced to differentiate with PMA; (E) macrophage morphology observed when HL60 cells, pretreated for 5 days with hFES-IP-sj1 and 2 ODN, are induced to differentiate with PMA; (F ) morphology of HL60 cells pretreated with hFES-AS-sj1 and 2 ODN and PMA induced. This panel is representative of the results obtained by several different experiments. Superimposable results are obtained with both the antisense strategies. Original magnification ×1,000.

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