Physical map of the 11q22 region and the structure of the DDX10 gene and the NUP98 gene. Vertical arrows indicate breakpoints of both DDX10 and NUP98. Small horizontal arrows below the transcripts indicate primers used for RT-PCR. (A) A schematic outline of the P1 contig in 11q22. The BamHI restriction map around P90 is also shown. P107 is chimeric and its chimeric portion originates from chromosome 9. (B) Restriction map around the inv(11) breakpoints on 11q22 and its relationship to the DDX10 cDNA. B and E indicate the BamHI and EcoRI sites, respectively. Exons of the DDX10 gene are represented by boxes (not shown to scale) on the map. Two probes used for Southern blot analysis are shown above the map. (C) cDNA structure of NUP98.