Fig. 1.
(A) CD437 inhibition of HL-60R proliferation. HL-60R cells were seeded in RPMI 1640 at a cell density of 5 × 104 cells/mL. Cells were incubated overnight, after which vehicle alone (dimethyl sulfoxide at 0.1% final concentration) or CD437 (1 μmol/L final concentration) were added. Cells were harvested at various times and cell number determined using a hemocytometer. (B) HL-60R cells were grown as described above in the presence of various concentrations of CD437 for 48 hours. (C) HL-60 cells grown in the presence and absence of 1 μmol/L CD437, as described above. (D) K562 cells were grown as described above in the absence or presence of CD437 (1 μmol/L).
