Fig. 2.
Hematologic effects in the femur 48 hours after a single intraperitoneal dose of taxol (60 mg/kg) or intravenous doses of navelbine or vinblastine (both 10 mg/kg). CTL, control mice receiving no drug. Upper panels, total MNCs per femur; middle panels, clonogenic progenitors (CFU-C) per 105 MNCs plated; lower panels, total clonogenic progenitors per femur. Cultures were plated in triplicate; error bars in middle and lower panels denote standard deviations. In the middle panel, note that MNCs obtained from drugtreated animals are enriched for progenitors, reflecting inefficiency in the depletion of progenitors relative to nonclonogenic MNC.
