Fig. 3.
Hematologic effects in the femur 48 hours following SCF in combination with a single intraperitoneal dose of taxol (60 mg/kg) or intravenous doses of navelbine or vinblastine (both 10 mg/kg) as shown in Fig 1. SCF, control mice receiving SCF alone. Upper panels, total MNCs per femur; middle panels, clonogenic progenitors (CFU-C) per 105 MNCs plated; lower panels, total clonogenic progenitors per femur. Cultures were plated in triplicate; error bars in middle and lower panels denote standard deviations. Comparison of the middle panel with Fig 2 shows that sparing of progenitors is markedly reduced or abrogated by preceding SCF administration.