Prevention of both thrombocytopenia and neutropenia. PEG-rHuMGDF (2.5 μg/kg/d) singly for 7 days after hepsulfam, and adding daily rHu-GCSF (10 μg/kg/d) subsequently for 2 weeks restored the posthepsulfam platelet response produced by 2.5 μg/kg/d PEG-rHuMGDF alone (left) and abolished the period of neutropenia (right). The (○) depict the counts for untreated hepsulfam controls. The (•) represent counts in hepsulfam animals receiving 2.5 μg/kg PEG-rHuMGDF from day 1 through day 22, and 10 μg/kg rHu-GCSF from day 8 through day 22.