The gene organization of the γ-glutamyl carboxylase. (A) The nucleotide numbers are based on the numbers submitted to Genbank. The transcription initiation site at nucleotide number 515 is labeled with an overhead “➭”. The coding sequence is in uppercase boldfaced. The 5′- and 3′-untranslated regions are in lowercase italics. The intron sequences are shown in lowercase. The potential polyadenylation sites are underlined and capitalized. Each transcription stop site (identified by cDNA cloning) is double underlined and capitalized. (B) The intron-exon organization is shown. 5′ and 3′ untranslated regions are shown in gray scale, the exons are black, and the introns are represented by clear rectangles. Alu sequences are represented by arrows below the figure whereas the mer 20 sequence is represented by an arrow above the figure. Some restriction sites are shown above the figure.