Effect of a 2-week course of human growth factor (GF) injections on the number of various phenotypically and functionally defined human hematopoietic cells present in the marrow of NOD/SCID mice at 5, 10, and 16 weeks after the transplantation of 2 × 107 light density human marrow cells. Values shown are the mean ± SEM of results pooled from individually assessed mice analyzed in two separate experiments (two or three GF-injected mice and two to three control mice per time point per experiment). Fold change refers to differences seen in the GF-injected mice as compared with control mice that were transplanted with aliquots of the same original human marrow cells and were later injected with saline only. The control mice represent a subset of those used to generate the absolute values shown in Fig 5. Significant increases (P < .05, 1-tailed Student′s t-test), relative to values measured in control mice are indicated by an (*).
