Fig. 1.
In vitro sensitivity of TK and ΔTK-expressing T cells to GCV. LN cells were cultured for 2 days with ConA in the presence of increasing concentrations of GCV and pulsed overnight with 3H TdR (100% uptake is that observed in the absence of GCV in the culture). The dashed line indicates 50% proliferation. LN cells from EpTK-(▪) and EpΔTK-(•) transgenic mice are compared with cells from a nontransgenic (▴) FVB mouse. Comparable results were obtained in at least five independent experiments.
