Fig. 6.
Accumulation of 3[H]-daunorubicin into cytoplasts prepared from (⊡) U-A10 and (♦) U-937 cells. Cytoplasts were exposed to 0 to 750 ng/mL of 3[H]-daunorubicin for 1 hour before terminating drug accumulation by pelleting through silicone oil. Shown is a plot of the mean (± the standard error) daunorubicin accumulation into cytoplasts versus external drug concentration for three experiments each performed in duplicate. The differences were statistically significant at 500 (P < .005) and 750 ng/mL (P < .01) of daunorubicin.