Comparison of LMP-1 DNA sequences from cases TR-1, HD-1, HD-2, HD-3 with those of the EBV strains B95.8 and CAO NPC. Numbering of nucleotides is according to Baer et al.36 Codons containing potential hot spots are reported in italics. Point mutations affecting the amino acid sequence are reported. Silent mutations are underlined and deletions are indicated by dotted lines. Cases HD-1 and HD-2 showed an identical 30-bp deletion starting from codon 343, whereas case HD-3 had a 63-bp deletion starting from codon 334.